Mutations of the gene coding for calreticulin (CALR) that cause the loss of the C-terminal KDEL motif abolish its retention in the endoplasmic reticulum and cause CALR to be secreted from cells. Specific CALR mutants bearing a novel C-terminus can precipitate the manifestation of myeloproliferative diseases via the autocrine activation of the thrombopoietin receptor. We recently emplo... https://www.bekindtopets.com/super-find-Pet-Odor-Exterminator-Air-Freshener-Spray-Hippie-Love-7-oz-deal-zone/