Sickle cell disease (SCD) is caused by a single-point mutation. and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS). and reduction in bioavailability of vascular nitric oxide (NO). contribute to the pathogenesis of the disease. https://www.chiggate.com/tablecraft-widemouth-squeeze-bottle-cone-tip-16-oz-clear-for-sale/